Publication in Dalton Transactions

The copper(II) complexes of general formula [Cu(GL)(Cl)] (13, G = OMe, H and NO2, respectively), bearing tridentate Schiff base ligands (GL) and a chloride as a fourth labile one, are here reported. The Schiff bases derive from the monocondensation of ethylenediamine and substituted salicylaldehyde, where the electronic properties are modulated by the releasing or withdrawing power of the G group. The compounds were structurally characterized through single crystal Synchrotron X-ray diffraction experiments in the solid state. In vitro tests on cell viability were conducted on malignant cell lines. All compounds were capable of formation of intracellular reactive oxygen species and DNA intercalation. This is especially effective for 3 (NO2), which revealed the highest anticancer activity against malignant triple-negative breast cancer MDA-MB-231 cells.

Date: 29. oct 2020 | Author: agch

Department of Inorganic Chemistry

Faculty of Science
Palacký University in Olomouc

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CZ-771 46 Olomouc
Czech Republic

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