General Information

Research at the Department of Inorganic Chemistry principally focuses on syntheses of coordination compounds in these fields:

Biologically active coordination compounds

Research of biologically active complexes constitutes one of the key parts of bioinorganic chemistry. It was a simple complex of platinum – cisplatin, which became one of the fundamental pillars of this field. Cisplatin has been clinically used for the treatment of tumour diseases since 1970s. Thanks to the commercial success of cisplatin and its derivatives (carboplatin, oxaliplatin etc.), research focused on biologically active complexes of platinum as well as other transition metals is also today a very perspective field with high application potential. The research is continuous and has resulted in application or clinical testing of complexes of other metals in medicine, e.g. gold (auranofin, for the treatment of rheumatoid arthritis), titanium, ruthenium as well as new compounds of platinum (treatment of cancer).
Since the discovery of the cytotoxic activity of cisplatin, the focus has been on the anticancer complexes based on platinum. However, the studies on the anticancer properties of complexes of other transition metals have continuously risen to attention of scientists as well as research in other types of biological activity of the studied compounds. In these days, it is already common knowledge that anticancer activity is not restricted to platinum complexes, many various transition metal complexes have been characterized which exhibit better activity than cisplatin. Some of these compounds are currently undergoing clinical trials. Additionally, it has been widely established that transition metal complexes can show varied types of biological activity (e.g. anti-inflammatory, antiradical, antiviral, antibacterial).
At the Department of Inorganic Chemistry, the research of biologically active transition metal complexes has had a long-time tradition – there have been published works describing highly anticancer active Pt(II), Pd(II), Ru(III) and Fe(III) complexes, anti-inflammatory active Au(I) complexes, antiradical and antidiabetic active Cu(II) complexes with N6-benzyladenine derivatives, Pt(II) complexes of 7-azaindole, Fe(III) complexes of Schiff bases, Zn(II) complexes of kinetin derivatives and Cu(II) complexes of 2-phenyl-3-hydroxy-4(1H)-quinolinone derivatives.

Coordination compounds with extraordinary magnetic properties

Research of magnetic materials on the molecular level has undergone great development in the last decades. Concerning the influence on and tuning of magnetic properties, what is considered the most perspective area, is the preparation of coordination compounds. The mutual spatial arrangement of paramagnetic centres and their magnetic interactions can lead to wide variety of different properties. New materials with magnetic ordering can involve multidimensional molecular magnets, single-chain and single-molecule magnets. Discoveries and phenomena on the quantum levels exhibited in single-molecule magnets may lead to further miniaturisation of memory and display units and promise great development in information technologies.
Another very important group of paramagnetic compounds, without magnetic ordering, comprises spin-crossover compounds. This phenomenon can be observed for octahedrally coordinated complexes of 3d4-3d7 central atoms. Spin crossover can be understood as a thermodynamic transition between different spin states, which means that under the same conditions, at least two diverse spin states (differing in magnetic as well as other physical properties) can coexist. The equilibrium between these states depends on temperature, pressure and radiation. Technically most interesting examples have the spin transition occurring at room temperature. Additionally, thermal hysteresis should be observed (ca. 50 K wide hysteresis for practical use); this means that the compound can store information, which is potentially applicable in memory devices. Moreover, the spin transition is accompanied by a colour change and it is possible to change the spin state by electromagnetic radiation; these are very important properties usable in the construction of molecular sensors and switches.
At the Department of Inorganic Chemistry we concentrate on syntheses and study of magnetic properties of coordination compounds of, in particular, iron, manganese and nickel with modified Schiff bases or other types of organic compounds with varying terminal or bridging ligands. This research has so far led to the preparation of polymeric molecular magnets, mononuclear, polynuclear and polymeric spin crossover Fe(II) and Fe(III) compounds. Additionally, we focus on studies of magnetic exchange interactions and magnetic anisotropy, which are important for the properties of molecular magnets. We also study magnetism of polynuclear compounds of 4f metals and their heterobimetallic 3d-4f derivatives, which is currently the most perspective direction of magnetochemistry in the development of single-molecule magnets. 

Department of Inorganic Chemistry

Faculty of Science
Palacký University in Olomouc

17. listopadu 12
CZ-771 46 Olomouc
Czech Republic

tel: +420 585 634 351
fax: +420 585 634 357
email : agch(at)upol.cz